You will need the program Chimera to view and answer the following: Examine the

Question

You will need the program Chimera to view and answer the following:

Examine the structure of the double-stranded DNA oligomer that is in pdb file 3bse to answer this and the following questions:

1.) What is the width of the major groover? Measure the distance between phosphorus atoms in the backbone so that the line that connects them is approx. parallel to the helical axis of the DNA. Enter your answer in angstroms.

tip: the cartoons that are shown in the structure when it is first opened can be turned off as follows: actions-> atoms/bonds -> nucleotide objects -> off. The ribbon can be hidden: Actions -> Ribbon -> hide

2.) What is the width of the minor groove? Measure between phosphorus atoms parallel to the helical axis. Enter your answer in angstroms.

3.) The human genome contains approx. 3 billion base pairs. Based on the size of the DNA fragment in 3bse, calculate the length of a strand of DNA that contains 3 billion base pairs. Enter your answer in cm.

Question 5 1 pts Examine the structure of the double-stranded DNA oligomer that is in pdb file 3bse to answer this and the following questions. What is the width of the major groove? Measure the distance between phosphorus atoms in the backbone so that the line that connects them is approximately parallel to the helical axis of the DNA. Enter your answer in angstroms. Chimera tip: The cartoons that are shown in the structure when it is first opened can be turned off as follows: Actions->Atoms/Bonds->nucleotide objects ->off. The ribbon can be hidden: Actions->Ribbon-> hide. Question 6 1 pts What is the width of the minor groove? Measure between phosphorus atoms parallel to the helical axis. Enter your answer is angstroms Question7 2 pts The human genome contains approximately 3 billion base pairs. Based on the size of the DNA fragment in 3bse, calculate the length of a strand of DNA that contains 3 billion base pairs. Enter your answer in centimeters

Explanation / Answer

Answer.1] Width of major groove is 18-19 angstrom. distance between phosphorus atoms in backbone is 3.4 angstrom

2] width of minor groove is 12-13 angstrom. Distance between phosphorus atom parallel to thw helical axis is 2 angstrom.

3] distance between two bp is 0.34 angstrom and number of bases is 3 billion then length of DNA is 0.34x10-9 x 3x109 = 1.02 m or cm, hence length of DNA is cm

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