Use the mutations lab to answer the following two questions. Be sure to scroll d

Question

Use the mutations lab to answer the following two questions. Be sure to scroll down to see the full question. The below strand of DNA has had two consecutive cytosine (C) nucleotide bases deleted from its sequence A IA Alter the template DNA strand in the mutations lab as depicted above. Select the corresponding protein sequence that results from the mutation. Note that the sequences below only lists the first eight amino acids in a polypeptide chain, but there may be more depicted in the lab O O O O Met His Trp Thr Ala Cys Ala lIe Met His Trp Thr Ala Cys Leu Arg Met His Trp Thr Met Phe Ala lle Met His Tyr Gly Met Phe Ala lle What is this type of mutation called? O Frameshift mutation O Insertion mutation O Substitution mutation O Single-nucleotide polymorphism

Explanation / Answer

3’TGT ACG TAA CCT GGT ACA AAC GCT ATC TTG-5’DNA Template Strand

5’ ACA TGC ATT GGA CCA TGT TTG CGA TAG AAC ‘ 3’ – Coding DNA

5’ ACA UGC AUU GGA CCA UGU UUG CGA UAG AAC3’ mRNA Sequence

5’ Thr-Cys-Ile-Gly-Pro-Cys-Leu-Arg-Stop-3’ Amino Acid Sequence

There is Frameshift Mutation

Frameshift mutations are insertions or deletions in the genome that are not in multiples of three nucleotides. They are a subset of insertion-deletion (indel) mutations that are specifically found in the coding sequence of polypeptides. Here the number of nucleotides that are added or removed from the coding sequence are not multiples of three. They can arise from extremely simple mutations such as the addition or removal of a single nucleotide.

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