To assess bioavalability of a drug, investigators administered it ineravenously

Question

To assess bioavalability of a drug, investigators administered it ineravenously to a volurnteer and measured the plasma concentration of the drug over bme The invest gat ors subsequently administered the same dose of the drug and similarly measured the plasma concentration of the drug over time The curves were oraly to the same person plotted on the graph below Time Oral Which of the following is the best determinant of oral bloavailability of the drug in this person? O A Slope of the IV curve dvided by the slope of the oral curve O B Area under the oral curve O C. Madmal concentration at the peak of the oral curve O D. Rate of elimination for the IV curve divided by rate of elmination for the oral curve Area under the oral curve divided by area under the IV curve

Explanation / Answer

The correct answer is option E that is area under the oral curve divided by area under IV curve.

To determine the bioavailability of IV drugs, are under IV drug divided by are under oral drug should be taken.

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