The following figures depict the energetics of a catalyzed and uncatalyzed react

Question

The following figures depict the energetics of a catalyzed and uncatalyzed reaction. You mutate the enzyme involved in this reaction such that it bound to its substrate more tightly, with a 100x stronger affinity. This increases the depth of the trough labeled ES (so it is lower). Draw a graph depicting the free energy change versus reaction progress for the mutant enzyme, and label S, ES, P. and the activation energy. Would you expect the reaction rate catalyzed by be mutant enzy me to be faster, slower, or equal to that of the normal enzyme?

Explanation / Answer

the Ea increases when a mutant enzyme is introduced. ie.. the intermediate is more stable. ie, the intermediate is formed much faster. but the increse in actiation energy is very little . so, the reaction takes place faster.

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