A geneticist has obtained two true-breeding strains of mice, each homozygous for

Question

A geneticist has obtained two true-breeding strains of mice, each homozygous for an
independently discovered recessive mutation that prevents the formation of hair on the
body. One mutant is called naked, and the other is called hairless. To determine whether
the two mutations are alleles, the geneticist crosses naked and hairless mice with each
other. All the offspring are phenotypically wild-type; that is they all have hair on their
bodies. After intercrossing these F1 mice, the geneticist observes 115 wild-type mice and
85 mutant mice in the F2. Are the naked and hairless mutations alleles? How would you
explain the segregation of wild-type and mutant mice?

Explanation / Answer

in this form it is very difficult to understand the exact pattern for this type of inheritance, to choose the best suite for this 115:85 F2 you can use chie-square test statistics to compare the 115:85 with all dominance and epistatic ratios avilable in genetics, so the ratio with which 115:85 is giving the most matching will be the gene action working for this mutation, if it match with ratios of dominance then u can assume that the alleles are of the same gene and if it matches with the ratios of epistatic then the alleles are from the different genes interacting with the genes for hair formation in mice...

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