Exposure to sunlight, uv irradiation, produces pyrimidine dimers in skin cells.

Question

Exposure to sunlight, uv irradiation, produces pyrimidine dimers in skin cells. Several different repair enzymes are involved in the excision of these dimmers; when not excised they may produce tumors. This is xeroderma pigmentosum, XP.The enzymes are: an endonuclease that cuts the DNA at the dimer; an exonuclease the removes the dimmer; a polymerase that repairs the gap; and a ligase which reforms the phosphodiester
linkages. The condition is recessive and is caused by the absence of
a. the endonuclease b. the exonuclease c. the ligase
d. the polymerase e. any of these enxymes

Explanation / Answer

b. the exonuclease

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