1.A mis-sense mutation that converts the stop codon in a protein-coding gene to
ID: 230563 • Letter: 1
Question
1.A mis-sense mutation that converts the stop codon in a protein-coding gene to a codon that encodes an amino acid would have what effect on the production of that protein? (You may assume that the stop codon is followed by many codons that all encode amino acids.)
(A)No effect; protein synthesis would result in exactly the same protein as the normal gene would encode.
(B)The protein would be longer than the normal protein.
(C)Protein synthesis would terminate early; the mutant protein would be shorter than the normal protein.
(D)The protein would simply contain one different amino acid, compared to the protein encoded by the normal gene.
Explanation / Answer
OPTION-- D
Missense mutations CodeSfor a different amino acid. A missense mutation changes a codon so that a different protein is created, a non-synonymous change.
Conservative mutations Result in an amino acid change. However, the properties of the amino acid remain the same (e.g., hydrophobic, hydrophilic, etc.)
Non-conservative mutations Result in an amino acid change that has different properties than the wild type. The protein may lose its function, which can result in a disease in the organism.
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