Vasopressin is a peptide hormone (nine amino acids long) that stimulates water r

Question

Vasopressin is a peptide hormone (nine amino acids long) that stimulates water reabsorption in the kidney. Its receptor is an integral protein in which the domain of the receptor responsible for binding vasopressin is located on the extracellular side of the cell membrane. The receptor that binds the steroid hormone testosterone is located in the cytoplasm of its target cells.  

1) What type or types of amino acids do you expect to predominate in the vasopressin-binding domain of the vasopressin receptor? What type or types of amino acids do you expect to find the transmembrane region of the vasopressin receptor (this region has several alpha helices passing through the membrane)? Explain your reasoning

Explanation / Answer

1. Vasopressin also known as ADH . In most species it contain arginine and called argipressin togeather. it has a nine amino acid sequence as- cys-tyr- phe- gln-asn- cys- pro- arg- gly -NH2. these amino acid are find on the domain.

there is a different binding mode for agonist and antagonist.vasopresin is characterised by a cyclic structure, may be buried in 15-20 angstrom deep cleft defined by transmembrane helices of the receptor and interact with amino acids located inthe region.

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