Liposomes are promising molecules in gene transfer technology because of their s

Question

Liposomes are promising molecules in gene transfer technology because of their similarity to cell membranes and their charge interactions with negatively charged DNA. Estimate the charge on the outside surface of a liposome of diameter 1 micrometer. Suppose a typical phospholipid head has a diameter of 1nm and carries are charge of one proton (1.6021X10^-19 C). Assume that the surface of the spherical liposome is comprised of phospholipid heads packed together as tightly as possible in a configuration known as a hexagonal packing , which minimizes the inevitable vacant space that occurs when circles pack against one another.

Explanation / Answer

Thc interaction of a drug with lipid membranes in the body determines its ..... RESULTS: Gd-containing PEO-modified liposomes (average diameter 200 nm) were ...... negatively charged liposomes (PC, CH, and phosphatidylserine in a 4:5: 1 .... neutralize the DNA charge were much less efficient than positively charged ...

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