True statements about de novo fatty acid synthesis include A. It utilizes acetyl

Question

True statements about de novo fatty acid synthesis include A. It utilizes acetyl CoA from carbohydrates and occurs in the liver and adipocyte inner mitochondrial matrix. B. The rate limiting step involves a reaction in which acetyl CoA accepts a one carbon group from another acetyl CoA to form malonyl CoA. C. Acetyl CoA carboxylase is active only in its multimeric form which contains biotin in a N-carboxybiotin-enzyme complex. D. Fatty acid synthase is a complex enzyme in humans which is active as a homodimer. Each round of synthesis adds two carbons from malonyl-CoA to the methyl end of the fatty acid chain. The final product contains the original two carbons E. The acyl carrier protein (ACP) in the fatty acid synthase enzyme contains a biotin moiety esterified to a hydroxyl group of serine to provide the sulfhydryl group onto which the growing fatty acid chain is always attached.

Explanation / Answer

Fatty synthesis occurs from fatty acids and Acetyl co-A and in the presence of NADPH in the presence of enzymes called fatty acid synthases. Cytoplasm is the place where the process takes place. Acetyl co-A converted to fatty acid from carbohydrates by glycolytic pathway. The glycolytic pathway provides the glycerol by which 3 fatty acids combine to form glycerides through the process called lipogenic process.

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