252 Each body region differs chemically and physically from others, and thus pro

Question

252 Each body region differs chemically and physically from others, and thus provides a variety of selective environments for the growth of certain microbes but not others. Colonization of tissues by a pathogenic microbe followed by growth to form populations sufficient to trigger a biological effect is necessary before disease symptoms appear Q What common disease is a model for the study of bacterial attachment and colonization, and which species of bacteria cause the bulk of the damage in this 25.6 groical effect is necessary before disease? nathogen is a function of its

Explanation / Answer

Pneumonia is the common disease model for the study of bacterial attachment and colonisation. Bacterial colonization in the upper respiratory tract is the prerequisite for the infection. Successful colonizing bacteria must attach to the epithelial lining grow on the nutrient-limited mucosal surface and evade the host immune system. This attachment can be mediated by fibrillar protrusions (pili), surface anchored proteins, biofilms etc.

The species of bacteria that cause the bulk of damage in this disease are as follows:

1. Streptococcus pneumoniae

2. Haemophilus influenzae

3. Staphylococcus aureus

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