If a child were born with a mutation that made the ascending limb of the loop of
ID: 219696 • Letter: I
Question
If a child were born with a mutation that made the ascending limb of the loop of Henle permeable to water, what would be the minimum and maximum urine osmolarities the child could produce? Units are in mOsM. Could u explain?
minimum 100 / maximum 1200
minimum 100 / maximum 100
minimum 300 / maximum 300
minimum 300 / maximum 1200
minimum 100 / maximum 300
a.minimum 100 / maximum 1200
b.minimum 100 / maximum 100
c.minimum 300 / maximum 300
d.minimum 300 / maximum 1200
e.minimum 100 / maximum 300
Explanation / Answer
Ans. C. minimum 300 / maximum 300.
If mutation occur in the ascending limb of the loop of Henle which permeable to water then mutation affect the urine osmolarities.
Normally, The thin ascending limb of the loop of Henle brings tubular fluid around from the descending limb to the thick ascending limb. It is impermeable to water and urea but may be permeable to Cl.
when mutation cause the thick ascending limb does all the work of reabsorption, all parts of the loop of Henle are involved, including the vasa recta. It make characterized by impaired ability to concentrate the urine.
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