1. True/False: Like innate sensors of infections(TLRs, NLRs, RL Rs), antibodies

Question

1. True/False:
Like innate sensors of infections(TLRs, NLRs, RL Rs), antibodies frequentlyrecognize nucleic acids of pathogenic organisms.

2. Antibodies that bind with high affinity to some viral surface proteins require heavy chain CDR3 loops of unusual length. Whereas the average human heavy chain CDR3 length is ~15 amino acids, antibodies with VH CDR3 loops of >30 amino acids are readily detected in the repertoire. These antibody heavy chains with CDR3 lengths of >30 amino acids would likely be missing in individuals lacking:
A. RAG-1 and RAG-2
B. DNA-dependent protein kinase (DNA-PK)
C. The nuclease, Artemis
D. The Ku70:Ku80 complex
E. Terminal deoxy nucleotidyl transferase (TdT)

3. True/False:
The different classes of
immunoglobulins differ in the sequences of their
heavy chain constant regions. As a result, each
class of antibody has distinct effector functions.
Nonetheless, they are all found at about equal
concentrations in the serum of healthy
individuals.

Explanation / Answer

1. False

Justification : antibodies generally doesn't recognise the Nucleic acids. Majority of the antibodies are specific to protein or peptide binding.

3. False

Justification : different classes of immunoglobulins differ in the sequences of their heavy chain variable regions. The constant region is conserved in antibodies. Moreover, the concentration of different antibodies is not equal in serum.

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.