Wild-type S. cerevisiae and a genetic variant both have a the ADE2 gene. A trans

Question

Wild-type S. cerevisiae and a genetic variant both have a the ADE2 gene. A transcription activator known as Gcn4, upregulates ADE2 gene expression. The wild-type S. cerevisiae has a functional Gcn4 protein. However, the genetic variant has a frameshift mutation in the gene coding for Gcn4. Which of the following statements with respect to the ADE2 gene is CORRECT? a. The answer cannot be determined from the information provided. b. The organisms have the same receptor genotype but different phenotypes. c. The genotypes and phenotypes of both organisms are the same. d. The phenotypes of both organisms are the same, but the genotypes differ. e. The organisms have different genetic sequences for the receptor.

Explanation / Answer

Answer: Option B is correct.

Explanation: GCN4 binds to the upstream region of ADE2 and upregulates its expression.

So, GCN4 = Ligand and ADE2 = Receptor.

In the given case, both WT and mutant have functional ADE2 gene sequence. So, both of them possess same (functional) receptor genotype.

However, the mutant lacks GCN4. So, ADE2 can not be expressed in the mutant. SO, its phenotype will be different.

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