1. Positive selection of T cells occurs when the cell reaches which one of the f
ID: 217824 • Letter: 1
Question
1.
Positive selection of T cells occurs when the cell reaches which one of the following stages of development?
The CTLA-4+ stage
2.
For T cells, negative selection results in cell suicide because...
Thymocytes fail to express a TCR.
3.
During B cell development in the bone marrow...
The heavy chain is produced only if the kappa light chain has been successfully produced first.
4.
For some cancer patients, treatment with an antibody that binds and inhibits the function of CTLA-4 is beneficial because...
The pro-T stage.Explanation / Answer
Ans 1) The mature stage – The positive selection of T-cell occurs when the cell reaches the mature stage. This is the stage when the positive thymocytes move into the thymic cortex.
Ans 2) The T-cell receptors of thymocytes bind with high affinity to MHC+ antigen peptide. It expresses high affinity for the self MHC and hence leads to destruction of the T-cells.
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