Explain the biochemical definition of a conservative substitution and a non-cons

Question

Explain the biochemical definition of a conservative substitution and a non-conservative substitution. What is the likely outcome of each type of substitution (conservative substitution and a non-conservative substitution) on protein function? What is the difference between the statistical definition of the conservative and non-conservative substitutions and the biochemical definition of a conservative substitution and a non-conservative substitution? Is the BLOSSUM62 substitution matrix based on the biochemical properties of amino acid side-chains or the statistical analysis of amino acid substitutions?

Explanation / Answer

Explanation:- Conservative substitution is an amino acid replacement in which one amino acid is substituted by anaother amino acid of similar biochemical properties charge, hydrophobicity etc so that net effect on protein would be minimum.Non-conservative  substitution is an amino acid replacement in which one amino acid is substituted by anaother amino acid of different biochemical properties charge, hydrophobicity etc so that the protein so formed would have different properties.BLOSSUM 62 Blocks substitution matrix is sequence alignment of polypeptides based on statistical analysis of amino acid substitution.

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