2. In comparing Type I and Type lIl proteins, what is similar? Your answer 3. In

Question

2. In comparing Type I and Type lIl proteins, what is similar? Your answer 3. In comparing Type l and Type lI proteins, what is different? Your answer 4. In comparing Type I and Type IlI proteins, what is similar? Your answer 5. In comparing Type l and Type II proteins, what is different? Your answer 6. In comparing Type II and Type IIl proteins, what is similar? Your answer 7. In comparing Type Il and Type IIl proteins, what is different? Your answer 8. What defines a Type IV protein? Your answer

Explanation / Answer

I assume that we are talking about membrane proteins topologies.

2) Type 1 and type 2 are both single-pass molecules, it means they cross the membrane only once.

3)Type 2 have their amino terminus on the cytoplasmic side of the cell and the carboxy terminus on the exterior, while type 1 is the other way around.

4)Type 1 and 3 are both sub divided in classes and b. A if they have cleavable signal sequence or B if they do not.

5)Type 3 membrane proteins have multiple transmembrane domains in a single polypeptide chain while type 1 only crosses once.

6)Type 2 and 3 are anchored to the membrane with a signal-anchor sequence

7)Type 2 is targeted to the ER lumen with its C-terminal domain, while type 3 have their N-terminal domains targeted to the ER lumen.

8)Type 4 proteins have multiple homologous domains which make up an assembly that spans the membrane multiple times. The domains may reside on a single polypeptide chain or be on more than one indivdual chain.

Hope it helps! Good luck!

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