Home Tools L211 SP18 Proble… x Sign In 91.69% 1B) A common genetic technique use

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Home Tools L211 SP18 Proble… x Sign In 91.69% 1B) A common genetic technique used to determine the order and number of proteins involved in a pathway is complementation analysis Cell extracts from patient are used in the assays to measure DNA repair after UV irradiation. No extract by itself could repair a UV lesion [that is it exhibit the defects mentioned abovel, but when two extracts were mixed together, repair was observed If they were mutated inifferent part of the pathway. Each extract providing the normal protein together they complement each other and complete the repair process. Below is a sampling of just a few patient samples with different clinical features of XP, all of which individually had defects in UV repair by the assay mentioned above (and of course clinical feature of XP) O-No complementation when mixed, + = complement and normal DNA repair occurs upon UV irradiation Use the table above to answer if the following is TRUE or FALSE [4pts] i. ii. iii. Patients 1, 2 and 3 all suffer from XP as a result of mutations in the same gene. Patients 4,5 and 6 all have mutations in the same gene. Based on the results in table one can deduce that defects in at least 3 different genes can result in XP Based on the results in the table once can deduce that defects in at least 4 different genes can result in XP iv.

Explanation / Answer

1. False

because as you can see in image, one two and three have disease that is why when same extract mixed together they didn't produced normal result. But 1 and 2 have mutation at the same position that is why the mixing of 1 and 2 doesn't give normal result.

2. False

5 and six have same mutation and 4 have different mutation. By mixing of Extract 5 and 6 the normal Condition is not appeared. But 4 have different mutation because when we mix 4 with 5 and 6 then normal condition is appeared.

3.False

Extract 2 and 3 indicates that their location at the same point.

text at 5 and 6 indicates that their location at the same point. The remaining all gave the idea about different different mutation.

by table we got the idea that four different genes are involved in the XP.

1 &2 have same mutation, 3 is different mutation, 4 is different location, 5 and 6 have same mutation.

False

4. True as i mentioned in 3.

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