Hello everyone, this is a article about the cell cell adhesive molecules e cadhe

Question

Hello everyone,

this is a article about the cell cell adhesive molecules e cadherins and how downregulating them would result in the formation of tumor and cancer. and the effect of hdcg mutations on e- cadherins adhesive and activation. my question is pretty simple i hope someone can help me out. this is the results section. if someone could just pinpoint the important results found. i would just want to see if im on the right track.

thanks

Effects of germline HDCG mutations on E-cadherin adhesion and activation Numerous missense germline mutations in the E-cadherin gene have been implicated in the pathogenesis of diffuse gastric cancer (Carvalho et al., 2013). Several somatic missense mutations associate with breast cancer are also reported in the TCGA database, although compared with the HDGC mutations, it is less clear whether they are causal; therefore we decided to focus on the well-documented causal HDCG germline mutations. Many cause amino acid substitu- tions at different regions of the extracellular domain (Table 2; also see Figure 6 later in the paper), and most are not in regions believed to have a direct role in cadherin homophilic binding interactions per se. Although a few of these have been suggested to cause defects in adhesion as a result of cursory assays (Suriano et al., 2003; Brooks Wilson et al., 2004; More et al., 2007), we sought to test rigorously whether they still mediate homophilic adhesion assay and, if so, how well. We used a well-established quantitative adhesion assay that

Explanation / Answer

The important results found are:

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