In the first stage of RNA interference, a ___________________ RNA precursor is c

Question

In the first stage of RNA interference, a ___________________ RNA precursor is cleaved by the ____________ enzyme
The cleaved molecules are approximately _____ (insert number) bases in length and are called __RNA if the RNA
originated from a virus or __RNA if the RNA was of endogenous origin (if the RNA precursor was produced artificially, it’s
called __RNA). The cleaved RNA is then separated into __________________ RNA, which then binds to the ribonuclease
complex called _____________. The short RNA molecules can then target the complex to __RNA with a
__________________ sequence, which is then cut at that site.

WORD BANK: Words can be used once, more than once or not at all.
RNAi

complementary identical

mi

si

hp
m

r

t
RISC

Dicer

Single-stranded
sh

Double-stranded

Explanation / Answer

in the first stage of RNA interference,a double stranded RNA presursor is cleaved by the DICER enzyme. The cleaved molecules are approximately 20-25 bases in length and are called siRNA if the RNA originated from virus or miRNA if the RNA was of endegenous origin( if the RNA presursor was produced artificially,its called sh RNA). The cleaved RNA is then seperated into guide RNA, which then bind to ribonuclease complex called RISC. The short rna moleculescan then target the complex to mRNA with a complementary identical sequence. which is then cut at the site.

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