4. All of the following statements about mitochondrial-based human diseases are

Question

4. All of the following statements about mitochondrial-based human diseases are true EXCEPT: A) Mitochondria replacement procedures (that produce the 'three-parent babies') are just beginning to be performed. B) Mitochondria replacement would only be appropriate for those diseases that are caused by mutations in the mitochondrial genome. C) The inherence of mitochondria-based genetic diseases can be through either the maternal or paternal parent. D) Mitochondrial-based human diseases only affect muscle function

Explanation / Answer

4.C

It is not true. As we know that, sperm cell doesnot contribute its mitochondria to the egg cell during fusion. Sperm cell's mitochondria is self destructable. So, it is not inherited in the offspring. Mitochondria based diseases only inherited maternally. As mother egg cell contribute its mitochondria during fusion. Thus, the zygote formed after fusion has only materal mitochondrial DNA. So, the mitochondrial disease which is due to malfunctioning of mitochondrial DNA is purely maternally inherited.

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