Test Properties: The sensitivity of ReEBOV Antigen Rapid Test Kit was compared t
ID: 214914 • Letter: T
Question
Test Properties: The sensitivity of ReEBOV Antigen Rapid Test Kit was compared to the benchmark (gold-standard) assay. Sensitivity (95% CI) of ReEBOV Antigen Rapid Test Kit was 91.8% (84.5, 96.8) in comparison with the benchmark assay. While the specificity (95% CI) of ReEBOV Antigen Rapid Test Kit was 84.6% (78.8, 89.4) in comparison with the benchmark assay. Assume that you are a medical professional working in a region of West Africa where an Ebola outbreak has occurred. You are interested in how this test performs in your population. According to your calculations, about 50% of all individuals presenting to the clinic with Ebola-like symptoms are confirmed to have the Ebola virus (as determined via the benchmark, gold-standard method). 1. Fill out the following 2x2 table with numbers you might expect from the next 1000 patients preseanting to the clinic with Ebola like symptoms in this region Diagnosis (Gold-Standard) ReEBOV Ebola Not Ebola Total Total atc b+d 1000Explanation / Answer
Sensitivity: The sensitivity of a clinical test refers to the ability of the test to correctly identify those patients with the disease.
Sensitivity = True Positive (a) / [True positive (a) + False negative (c)]
= a / (a+c)
Specificity: The specificity of a clinical test refers to the ability of the test to correctly identify those patients without the disease.
Specifity = true negative (d) / [true positive (b) + True Negative(d)]
= d/ (b+d)
Ebola Not Ebola Total
Positive (+) 459 77 536
Negative (-) 41 423 464
a+c b+d 1000
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