MULTIPLE CHOICE. Choose the one alternative that best completes the statement or

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MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) The sequence Lys-Asp-Glu-Leu (KDEL) serves as an ER retention signal for proteins by binding to KDEL receptors that do which of the following? A) hold the proteins in the rough ER B) target ER proteins to recycling endosomes that return them to the ER C) transport the proteins from the Golgi apparatus back to the ER D) prevent vesicles from forming at KDEL receptor sites 2) Vesicles enter the Golgi apparatus by fusing with and they exit 2 A) the trans (concave) face; the cis (convex) face B) the cis (convex) face; the trans (concave) face C) other vesicles to form a new cisterna; the ERGIC D) the ERGIC; the cis (convex) face 3) True or False: Vesicle formation is driven by the binding of clathrin or COP proteins.3) Explain your answer below. A) True B) False 4) Newly synthesized membrane lipids are found on both the cytosol and lumen surfaces of 4) the membrane, yet they are only synthesized on the cytosolic face. How do they move from one side of the membrane to the other? A) transported by lipid transfer proteins B) enzymes called lipases help move them C) lipids can spontaneously move from one side to the other D) enzymes called flippases help move them SHORT ANSWER. Write the word or phrase that best completes each statement or answers the question. 5) Proteins that span the membrane multiple times are inserted as a result of an s 5) alternating series of internal sequences. sequences and transmembrane-

Explanation / Answer

1) The sequence lys-asp-glu-leu(KDEL) serves as an ER retention signal for proteins by binding to KDEL receptors that HOLD THE PROTEIN IN THE ROUGH ER

2) Vesicel enter the golgi appartus by fusing with ERGIC i.e endoplasmic reticulum-golgi intermdeiate compartment, and they exit THE CIS FACE.

3)TRUE the vesicle formation is driven by binding of clathrin or COP proteins. It is because these coat proteins induce curvature in membranes to form vesicles. They may either directly or indirectly interact with the molecular cargo being internalized.

4) Newly synthesised membrane lipids are found both on the cytosol and lumen surface of membrane, yet they are only synthesised on cytosolic face. They ARE TRANSFERRED FROM ONE SIDE TO ANOTHER BY LIPID TRANSFER PROTEINS.

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