1. order for most cancers to develop, tere must be an ncreasengenre sabar A. Tru
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1. order for most cancers to develop, tere must be an ncreasengenre sabar A. True B. False is the result of accumulated mutations within a single cel. Consistent A. True cause human cancers are mutagens that damage 3. There are essentially two distinct 'Restriction paints' (R1 and R2) depending on where you start the cell oycle 4. FLIP blocks the death by design pathway by interiering 5. The Ink4 locus expresses two genes-Ink4 and Arf-that prevent Rb hypophosphorylation and destabilize p53 DNA with this observation, most agentsthat B. Faise A. True B. False with the death domain (DD) on the death receptor (CD86) A. True B. False respectfully A. True B. False 6 Cancer is thought to arise from adul stem ceils because of their limited potency to differensate A. True B. False 7. Loss of mitochondrial function during apoptosis is caused by cytochrome c release from the mitochondria, which disrupts the flow of electrons to oxygen in the electron transport chain. A. True B. False 8. Caffeine is a suppressor of the p-adrenergic response virtue of suppressing a phosphodfiesterase that convers A. True B. False 9. Oncogenic Ras proteins have mutations that have noeased that ests numeratehdoyssofG7P A. True B. False 10. inhibition of protein synthesis in cancer cels lats to apoptic cel death meserse seramatr A True B. FaiseExplanation / Answer
1 ans- True
Genetic instability is a most prominant characterstic of most cancer type that has an important role in tumour formation by accelerating the accumulation of genetic changes.
2ans- True
Cancer caused by accumulation of a number of mutations in somatic cells, cell accumulates specific mutations over a long period of time and change in an organism’s DNA sequence.
3 ans- Fale
cell cycle check points are
G1 checkpoint - also called restriction point or start point of the cell cycle.
G2 check point start of mitosis and chromosome alignment.
M checkpoint- metaphase to anaphase transition where chromatid seperation occured.
4 ans-True
Death receptors such as Fas/APO1 expressed by human placental cytotrophoblasts which contain cysteine-rich ligand-binding domains (CRD) and intracellular death domains (DD)and FLIP block this pathway by interfering with the DD.
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