3. (4pts each) Suppose you expose cells to drugs with the following effects. Wil

Question

3. (4pts each) Suppose you expose cells to drugs with the following effects. Will these tend to promote microtubule growth, shrinkage, or neither? Please provide a brief explanation. A. The drug inhibits the exchange of GTP into and GDP out of free tubulin dimers B. The drug inhibits hydrolysis of the GTP bound to tubulin in microtubules. C. The drug increases the affinity of tubulin dimers carrying GTP for other tubulin dimers. D. The drug increases the affinity of tubulin dimers carrying GDP for other tubulin dimers. E. The drug increases the affinity of alpha and beta tubulin monomers for each other within tubulin dimers

Explanation / Answer

Tubulin bound to GTP promotes the growth of microtubule but when this GTP hydrolyzes to GDP, depolymerization happens since we can understand that hydrolysis will provide energy to the assembly thus making it less stable.

A)Neither more polymerization will take place nor depolymerization since neither more GTP will bind to cause polymerization nor GDP will be tubulin disassembly will take place.

B)since the hydrolysis of GTP to GDP is inhibited growth will be promoted

c) Since the affinity has increased rate of polymerization will increase, growth will be promoted

d)This will tend to increase depolymerizations, shrinkage will be promoted

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