In many tumors , promoter methylation plays a major role in regulating tumor sup

Question

In many tumors , promoter methylation plays a major role in regulating tumor suppressor genes. In some breast cancer tumors methylation inactivates the estrogen receptor gene, making the tumor ER negative. If I were to design a drug that targets a key DNA methyltransferase what effect might I want that drug to have on the methyltransferase and how would the drug impact ER gene expression. In many tumors , promoter methylation plays a major role in regulating tumor suppressor genes. In some breast cancer tumors methylation inactivates the estrogen receptor gene, making the tumor ER negative. If I were to design a drug that targets a key DNA methyltransferase what effect might I want that drug to have on the methyltransferase and how would the drug impact ER gene expression.

Explanation / Answer

In breast cancer, interruption of estrogen receptor (ER)- function is an effective therapeutic strategy. Despite the clinical benefit of interruption of ER- function, the precise biological action of ER- in breast tumors is not completely understood. It is clear that the ER- promotes the growth of breast cancer cells by targeting expression of signaling components of the insulin-like growth factor system. Intriguingly, it has the possibility that unliganded ER- itself may affect gene expression and breast cancer biology, and they suggest a potential mechanism for ER- to stimulate proliferation in breast cancer. As the survival of  ER-negative breast cancer patient is poor than the ER-positive, therefore the drug should be targeted for the inhibition of methyltransferase and would enhance the expression of ER gene

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