1) How may proto-oncogenes become oncogenes? c) mutations or chromosome re-arran

ID: 213502 • Letter: 1

Question

1) How may proto-oncogenes become oncogenes?

c) mutations or chromosome re-arrangements that cause over-expression of the proto-oncogenes

d) chromosome re-arrangements that cause loss of function of the proto-oncogenes

e) deletion of the entire gene

2) Discussing the function of APC/C complex (anaphase promoting complex): which of the following statements is correct?

d) activated APC/C complex eventually leads to cohesin degradation

a) epigenetic changes that lead to gene silencing of the proto-oncogenes

1. C. mutations or chromosome re-arrangements that cause over-expression of the proto-oncogenes

2. d) activated APC/C complex eventually leads to cohesin degradation.

Activated APC/C complex degraded securin which inhibits the separase molecules. After securin degradation, separase degrade cohesin molecules.

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