Based on the hydrophobic collapse model for protein folding, which of the follow

Question

Based on the hydrophobic collapse model for protein folding, which of the following conditions can denature a protein?

~~~~~~~CHOOSE ONE OR MORE~~~~~~~

A.Adding glycerol stabilizes hydrophobic residues on the protein surface.

B.Changes in pH break salt bridge interactions that stabilize the sequesteration of hydrophobic residues into the protected core of the protein.

C.Lowering the protein concentration changes the hydration surface, altering residues that partition into the hydrophobic core.

D.Heating proteins leads to exposure of the hydrophobic core, disrupting folding.E.Exposing the protein to white light causes the hydrophobic residues to cluster in the core.

Explanation / Answer

D) Heating proteins leads to exposure of the hydrophobic core, disrupting folding. It was observed that when high heat is applied to the protein, according to the hydrophobic collapse it leads to denaturation of the protein and opening its structure.

B) Changes in pH breaks salt bridge interactions that stabilize the sequestration of hydrophobic residues into the protected core of the protein. This impacts the proteins as it weakens the bonds and leads to opening of the structure causing denaturation.

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