Ls4203_class test_2017 please answer only question no.1. (5marks) Y How many mol

Question

Ls4203_class test_2017

please answer only question no.1.   (5marks)

Y How many molecules of ATP will be produce by the complete aerobic oxidation of the following compound? With explanation. 2. How cholesterol biosynthesis is regulated? Explain the mode of action of stetin group of drugs? What are the important biomolecules formed from Isopentenyl pyrophosphate? And what are the important biomolecules formed from cholesterol? 3f What are the needs of Cytochrome p-450 in the fatty acid synthesis? Give example of two essential fatty acids? Is arachidornic acid belongs to oa3 or fatty acids family? What is the function of Lipoxygenase? Discuss the mode of action of Aspirin. 4. What is glycerogenesis? How glycerogenesis regulate Triacylglycerol cycle? In which organ glycerogenesis is taking place and in which organ triacylglycerol cycle taking place? 2+1+1+1-5 0

Explanation / Answer

The Given structure is Oleic acid consist 18 carbons with 1 double bond at 9. Now for the activation of oleate to oleoyl Co-A the energetic cost is equivalent to 2 ATP. This Oleoyl Co-A will enter into the Beta Oxidation.

Beta Oxidation

To the del position 9, there will be three beta oxidation reaction and will produce 3 acetyl Co-A and cis del3 Dodecenoyl Co-A. After that an isomerase, isomerises the position of double bond from 3 to 2. So, there will be 5 more beta oxidation reaction and will produce 6 acetyl Co-A.

There will be total 8 beta oxidation and 9 acetyl Co-A will be produced.

8 beta oxidation will produce 30.5 ATP. (due to double bond at 9 acyl Co-A dehydrogenase will be skipped and 1 FADH2 will not be produced.)

1 NADH = 2.5 ATP

1 FADH2= 1.5 ATP

Now these produced 9 acetyl Co-A will enter TCA cycle. 1 TCA cycle will produce 3 NADH, 1FADH2, 1 GTP. So, for 9 acetyl Co-A will produce 27 NADH, 9 FADH2, 9 GTP entering into Oxidative phosphorylation (ETC) will produce 90 ATP.

Now the total production of ATP will be

30.5 + 90 – 2 = 118.5 ATP

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