1.A What is the chance that a woman homozygous for beta thalassemia and a carrie
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1.A What is the chance that a woman homozygous for beta thalassemia and a carrier man can have healthy children? codon created site abered site Figure 7.5 The p globin gene, showing he positions of eight mutations(labeled 1-8) that produce ßthelessema oyeater lesser severity These eight are represen. tative of about 100 .thalossema mndations deletion B. What if the woman is actually heterozygous for mutations 3 and4 of the beta 160 globin gene, and there is a 30% chance of recombination between the two sites? globin gene and there1s actually heterozygous for mutations 2 and 5 of the beta 60, globin gene, and there is a 40% chance of recombination between the two sites? D. What if the woman is actually heterozygous for mutations 6 and 7 of the beta globin gene, and there is a 10% chance of recombination between the two sites? E. What if the woman is actually heterozygous for mutations 1 and 5 of the beta globin gene, and there is a 50% chance of recombination between the two sites?Explanation / Answer
Thalessimia is an autosomal recessive disease. If the woman is homozygous bb and the man is a carrier i.e. heterozygous Bb
bb x Bb
B b
b Bb bb
b Bb bb
50% of the offspring will be healthy but will be carrier of the disease.
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