Supercoiling is an important property of DNA tertiary structure that affects ess

Question

Supercoiling is an important property of DNA tertiary structure that affects essential processes such as replication and transcription How do cells maintain DNA in a negatively supercoiled state? O Only protein free closed-circle DNA molecules are able to maintain a negatively supercoiled state. Only nicked, circular molecules of DNA can maintain a negatively supercoiled state. Only linear molecules of DNA can maintain a negatively supercoiled state. To maintain a negatively supercoiled state, the DNA molecule needs to either be a closed circle or if linear, constrained at both ends by proteins. Which structural changes become more favorable when a DNA molecule is negatively supercoiled? DNA triple helix formation formation of Z-form DNA formation of A-form DNA Strand separation cruciform formation

Explanation / Answer

1. Option D is correct.

A negatively supercoiled state can be achieved in both linear and circular DNA molecules with the help of associated proteins.

2. Options B, D, and E are correct.

The following structural changes become more favorable when a DNA molecule is negatively supercoiled

i. It is easy to separate both the strands

ii. Z-DNA formation is favored

iii. Cruciform formation is favored

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