Supercoiling is an important property of DNA tertiary structure that affects ess

Question

Supercoiling is an important property of DNA tertiary structure that affects essential processes such as replication and transcription How do cells maintain DNA in a negatively supercoiled state? O O Only protein free closed-circle DNA molecules are able to maintain a negatively supercoiled state. Only nicked, circular molecules of DNA can maintain a negatively supercoiled state. To maintain a negatively supercoiled state, the DNA molecule needs to either be a closed circle or if linear, constrained at both ends by proteins. Only linear molecules of DNA can maintain a negatively supercoiled state. correct. the DNA molecule is protein free and has a single stranded break, then the two strands will be free to rotate around each and revert back to the relaxed state. Which structural changes become more favorable when a DNA molecule is negatively supercoiled? DNA triple helix formation cruciform formation Strand separation formation of A-form DNA formation of Z-form DNA

Explanation / Answer

DNA super coiling is important for DNA packaging within all the cells nucleus this reduces the space taken by the DNA inside the nucleus .. this is greatly necessary at the time of nuclear divisions such as mitosis and meiosis .. proteins such as condensins and cohesion’s which are structural maintenance chromosomes proteins help in maintaining the super coils in the DNA ... and topoisomerases play the role in release of the super coils , unwinding of the DNA and maintenance of the DNA at the time of replication... so to maintain a negatively supercoiled state the DNA molecule needs to either be a closed circle or linear constrained at both ends by proteins

Structural changes which become more favourably by negativity supercoiled DNA is cruciform formation which can be further divided into folded and unfolded cruciform DNA .

Related Questions

Navigate

• Browse (All)
• Browse S
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.