In this pedigree, individual F has a sibling with a rare condition (indicated wi

Question

In this pedigree, individual F has a sibling with a rare condition (indicated with the swirl) and individual G has a sibling with a different rare condition (indicated with the stripes). The parents of F (individuals A and B) and the parents of G (individuals C and D) are also unaffected.

Individuals F and G have four children: K, L, M, and N. K has the same condition as H and M has the same condition as E. L and N are unaffected by either condition.

There is one gene responsible for each condition and the genes responsible for these genetic conditions segregate independently because they are on different chromosomes.

a) What is the simplest explanation of the mode of inheritance for the condition affecting individuals E and M?

b) What is the simplest explanation of the mode of inheritance for the condition affecting individual H and K?

c) What are the genotypes of individuals F and G?

d) What is the probability of each possible genotype for individual N?

e) If individual N has children with an individual affected by both conditions (P), what is the probability of each possible genotype and phenotype for this child (Q)?

Explanation / Answer

a) The mode of inheritance can be autosomal recessive inheritance.

b) Autosomal recessive inheritance.

c) The genotype of F And G could be the female could be carrier of the disease without expressing it and the male will be normal.

d)For the individual N either the daughter will be fine or the daughter would be the carrier of the disease on one of the X chromosome and transferring it to males and daughter but she will be also a carrier.

e) If individual has children the probability of being a carrier is if it is a female. If he will be a male then the probability of bring affected will be 1/2 and for female it would be 1/4.

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