Question 2 (35 points): Refer to the assigned document: “Dengue_Diagnostics_Reco

Question

Question 2 (35 points):     Refer to the assigned document: “Dengue_Diagnostics_Recommendations_Combined_DPBs.pdf”

A. (20 points) The article discusses the evaluation of several commercially available dengue IgM detection kits, which measure anti-dengue virus IgM in human blood. Describe in conceptual detail how the IgM detection assays might work. Consider: A) What steps are involved in sample processing and its assay to allow a reliable measurement? B) What kinds of problems could affect the performance of the kits?

Explanation / Answer

ANS A) Steps involved in sample processing and its assay:

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ANS B) Problems that could affect the performance of the kits are:

Be that as it may, both false-positive and false-negative outcomes can happen with the routinely utilized immunoglobulin M (IgM) serology tests.The IgM catch measure is thought to be more particular, and subsequently, its utilization is demonstrated for corroborative testing, yet its relative execution has not been completely assessed.These antibodies are not dependably recognizable until 3– 4 days post side effect beginning and requires the accumulation of a moment blood test 14– 21 days after the principal visit for a conclusive determination. Serological determination does not consequently illuminate quick treatment choices amid intense sickness. Since dengue patients regularly introduce inside 3 days PSO, false negative outcomes with immunizer based tests remain a worry.

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