The CDC has shown interest in Wolbachia research because of the symbiotic associ

Question

The CDC has shown interest in Wolbachia research because of the symbiotic association between Wolbachia sp. and filarial worms. Thus, this organization is offering grants to researchers who explore strategies that interfere with or control Wolbachia existence in filarial worms, such as those implicated in Elephantiasis. You want this money for your laboratory and believe you have a solid plan that is in accord with the CDC’s request. Your charge is to craft a “letter of interest” to the CDC that describes your plan and gives reasons why your plan should be funded. While this is a “letter” it should be lengthy enough (i.e., a preprosal) so that the CDC is clear on what you will explore, how your plan would be implemented and what you expect the outcome to be.

Explanation / Answer

The research topic That I have selected is " Control of Wolbachia in rodents , provides evidence for control of filarial infections". I have previously resaerched about this topic and I wish to proceed it further and I request you to fund this project. I am sure it is great challenge and provide you with many informations in this area of research. The details of the research is attached below.

Title

Control of Wolbachia existence in Rodents , provides evidence for control of filarial infections.

Abstract

Millions of people around the world are infected by Filarial worms. There is a endosymbiotic relationship between filarial worm and Wolbachia bacteria. Treatment by Tetracycline to this bacteria in rodents provides evidence that filarial worms donot survive in the absence of Wolbachia. This study also provides insight in the treatment options for filarial infections.

Introduction

Filarial nematodes depend on Wolbachia for its survival in the host. Wolbachia and Filarial nematodes are endosymbionts. Filarial worms in the absence of wolbachia are unable to survive. Filarial worms in its DNA contain a fragments that are originated from Wolbachia. These findings proved that Wolbachia are endosymbiontswith filarial nematodes since long time . Wolbachia is dependent for aminoacids that are derived from the worm and inturn filaril worms depend on wolbachia for heme , riboflavin and nucleotide biosynthesis. Hence by disrupting this endosymbiotic relationship , the growth of filarial parasite in the host can be reduced . For this disruption , tetracycline antibiotic is used which is proven effective against Wolbachia.

Methods

Based on the ethical guidelines , 20 rats are procured and used for analysis. 10 rats are used as control and 10 rats are used for testing the growth of filarial parasite. The rats that are tested are injected with Wolbachia and filarial parasite. The rats are allowed for the development of filariasis and other filarial related complications. Tetracycline is injected in all the rodents which contain Wolbachia and Filaria.

Results

After a week the symptoms of Filariasis must be reduced as the tetracycline declines the growth of Wolbachia . Thus filarial parasite depending on Wolbachia for its growth will also be reduced.

Discussion

Wolbachia free filarial worms cannot survive long in the host as they are unable to produce heme , riboflavin and other essential components. They are also unable to acquire these components from the surroundings.

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