Bacteriophage T4 contains a double-stranded DNA genome that is both circularly p

Question

Bacteriophage T4 contains a double-stranded DNA genome that is both circularly permuted and terminally redundant. T4 encodes its own DNA polymerase and several other replication proteins. After a T4 virion penetrates a host cell, viral genes are expressed and regulated so as to redirect the host synthetic machinery to make viral nucleic acid and protein. Early viral genes encode viral genome replication events; middle and late viral genes encode structural proteins and capsid assembly. Once T4 components have been synthe- sized, new virions are made, primarily by self-assembly, and the virions are released after lysis of the host cell. Q Bacteriophage T4 lacks its own RNA polymerase. How do T4 genes get expressed or converted to mRNA? What host barriers must be broken before release of virions from the host cell?

Explanation / Answer

T4 bactriophase infect E coli cells and produce new particles. After entry odd DNA into the cell it stars encoding m RNA for various genes with help of bacterial RNA polymerase although it has no gene for its own RNA polymerase.

After making all the necessary component, new virus particles are formed within the cell. These particals are released from the cell by breaking physical barrier like plasma membrane and cell wall with the help of T4 lysozyme which degrade the cell wall.

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