3. What factors affect the way virulence of a pathogen evolves? How could you ma

Question

3. What factors affect the way virulence of a pathogen evolves? How could you manipulate your pathogen's environment to maintain maximum virulence?

4. What are the relative roles of point mutations, horizontal gene transfer, phage, and genome rearrangements in the evolution of pathogens?

5. What is R? How does R evolve when a pathogen switches to a new host? If R is less than 1, will the pathogen survive? Greater than 1?

6. for your pathogen for world domination: How could you design your pathogen to avoid the tradeoff between virulence and transmission?  

Explanation / Answer

Virulence of a pathogen, depends upon the following factors like the pathway of entry of the pathogen into its host,attachment of pathogen to their host and how much early pathogen suppress the immune system of the host.The nutritional aspects that's the pathogen obtains from their host also regulate the virulence or disease causing process.

Manipulation of virulence from pathogen is increased by the providing specific environment for the pathogen growth and development.Example by providing certain factors like adhesion help in the attachment of pathogen, injection of certain enzymes that mobilizes the food used for the production of food for pathogen,transfer of genes can also be increased by use of certain cellulolytic enzymes.

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