2. You have a dish of mammalian cells in culture that are all about to enter mit

Question

2. You have a dish of mammalian cells in culture that are all about to enter mitosis (it is a synchronously replicating culture of cells). You add to the dish a drug that is a potent inhibitor of RhoA activity. Two hours later you analyze your cells under the microscope. Which of the following best describes what you might observe? (1 point) All cells appear to be in telophase. O All cells appear to be at metaphase. Around 50% of cells appear to be in anaphase A. All cells have completed mitosis Around 50 % of the cells have undergone apoptosis. . Which of the following is an event occurring during cellular apoptosis? (1 point) O Ligation of genomic DNA fragments to produce a DNA ladder O Rapid uptake of cytochrome c by mitochondria. Decondensation of genomic DNA on the inner wall of the nuclear envelope Rupturing of cells. Loss of phospholipid flippase activity 4. Which of the following mutations would be likely to result in formation of S. pombe cells that are enlongated and which require a long time to complete mitosis? (1 point) O O 0 0 O A mutation that abolishes Wee1 activity A mutation that increases activity of Cdc25. A mutation that increases activity of CAK. A mutation in CDK that prevents it from being phosphorylated by Wee1 A mutation that abolishes Cdc25 activity

Explanation / Answer

1) Answer : All cells appear to be in the telophase.

Because, rhoA regulates cytoskeleton elements such as actin and myosin during, contractile ring formation. Cytokinesis requires contractile ring formation which helps in separating daughter cells after mitosis. Cytokinesis cannot happen when rho A activity is inhibited therefore cells remain in telophase.

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