This is a biochemistry question This answer is wrong, please help! What is the m

Question

This is a biochemistry question

This answer is wrong, please help!

What is the most likely cellular effect of a large genomic deletion that removed the gene encoding the enzyme responsible for adding the 5 prime guanosine cap to eukaryotic mRNAs? (e) There would be a global decrease in tRNA and mRNA stability. There would be a negligible decrease in mRNA stability but protein synthesis would be unchanged. Cells would not survive due to a global decrease in mRNA stability and protein synthesis. Transcription initiation would fail, resulting in no transcription.

Explanation / Answer

Answer - Cells would not survive due to global decrease in mRNA stability and protein synthesis.

5' Cap is added to the eukaryotic mRNA after mRNA synthesis after transcription. This is the step comes under post-transcription modification. Cap is important to maintain the stability of mRNA in the cytoplasmic side. With out CAP the mRNA is degraded by the enzymes and protein synthesis is halted. Without protein, cells not able to function properly and leads to death.

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