This is a biochemistry question This answer is incorrect. Please help To efficie
ID: 208082 • Letter: T
Question
This is a biochemistry question
This answer is incorrect. Please help
To efficiently and accurately remove introns from pre-mRNA, how does the spliceosome identify and position the pre-mRNA in the active site? There is base pairing between the snRNA and the transcript. The C-terminal domain of RNA polymerase ll signals the position of the intron-exon The intron is a specific size so that it fits into the active site of the spliceosome. Spliceosomal proteins recognize the sequence at the splice site.Explanation / Answer
Answer-a) There is base pairing between the snRNA (small nuclear RNA) and the transcript.
During the process of splicing of the precursor mRNA, the spliceosome machinery binds to the exon-introm boundary. The introns are removed and the exons join together to form the functional gene for transcription and translation. The snRNA( small nuclear RNA) binds to and base pairs to the precursor mRNA nucleotides before splicing the introns from the exons leading to the formation of the functional gene.
The RNA polymerase C domain binds to the mRNA during the process of transcription and is not related to splicing event. Hence answer (b) is incorrect.
The introns are removed due to the binding of the spliceosome machinery and the exons join together. Hence answer (c) is incorrect.
The spliceosome complexes recognize the splice sites at the exon-intron junctions but the binding of the snRNA and spliceosome machinery directs the removal of the intron and joining of the exons. Hence, option (d) is incorrect.
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