Based on your understanding of the events surrounding cell death, which of the f

Question

Based on your understanding of the events surrounding cell death, which of the following incorrectly matches a mutation with its effect on apoptosis? A. Mutation in Bax that prevents homodimerization would inhibit Bax-mediated mitochondrial release of cytochrome c, having a negative effect on apoptosis levels B. Overexpression of Bcl-2 would induce apoptosis by promoting Bax/Bak oligomerization C. Non-phosphorylatable Bad would decrease apoptosis by constitutively binding to Bcl-2 D. Functional CED-9 and nonfunctional CED-3 would broadly inhibit apoptosis

Explanation / Answer

D. Functional CED-9 and nonfunctional CED-3 would broadly inhibit apoptosis.

Because , No death is observed in cells destined to undergo apoptosis when CED-3 function is abrogated (Ellis and Horvitz, 1986). Therefore, CICD in C.elegans does not appear to occur. In as far as it has been investigated, CICD rarely occurs in Drosophila melanogaster. Cells survive apoptosis induction in the absence of caspase activity in D.melanogaster(Fraser et al., 1997; Muro et al., 2006). Although recent studies have demonstrated alternative cell death pathways occurring in C.elegans and D.melanogaster, these do not fall under our definition of CICD since they manifest in the absence of caspase inhibition (Abraham et al., 2007; Berry and Baehrecke, 2007). The failure of cells in both C.elegansand D.melanogaster to undergo CICD is probably due an absence of MOMP in these organisms (Varkey et al., 1999; Zimmermann et al., 2002).

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