1. Using a table that shows which codon represents which amino acid (such as Fig
ID: 207275 • Letter: 1
Question
1. Using a table that shows which codon represents which amino acid (such as Figure 8.2 in your book), determine the following: A) The possible codons that encode Arginine: B) The amino acids that could be encoded if the 2nd position of the AAA codon that encodes Lysine was changed to one of the other 3 bases: C) If you know the sequence of one codon for a particular amino acid, and you had to guess what the sequence of the other codons were, what positions would you have a better than random chance of being able to predict what the sequence was? ou are studying the tryptophan synthetase gene that Yanofsky also examined to determine the relationship between the nucleotide sequence and the amino acid sequence of the gene, as illustrated in Figure 8.3) A) Yanofsky found a large number of mutations that affected the tryptopharn synthetase gene. How did he find these mutations and why do you think he probably not recover missense mutations in a big stretch of the gene that encodes the part of the protein between amino acids 49 and 175? 2. Y B) You start by looking at the mutations that Yanofsky recovered. One of these mutations affected amino acid number 49 and changed it from Glutamic acid to Valine. If you took this mutant E. Coli line and exposed it to a mutagen that could potentially change bases, insert bases, or delete bases, what type of second mutation could you discover that would create a wild-type tryptophan syn gene and where would it be located? thetaseExplanation / Answer
1) a) codon encodes Arginine are - CGU, CGA, CGC, CGG, AGA AND AGG.
b) AAA codes for lysine if we change the second base then codon will be AUA, ACA and AGA which codes for Isoleucine, Threonine and Arginine respectively.
c) third position of the codon because degeneracy of the codon is due to third base.
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