Note: Respond To All Questions From Part A To D A. B. C. What is the Kd for drug

Question

Note: Respond To All Questions From Part A To D

A. B. C. What is the Kd for drug A? What is the Kd for drug B? What is the Kd for drug C? If these three drugs antagonized the action of the normal ligand - that is they interfered with the binding of the normal ligand- and the binding of the normal ligand stimulated cell division, which one would be the best drug to interfere with the process of cell division as triggered by activation of the receptor by the normal ligand? Click to select) (Cick to select) Drug B Drug A Drug C Ligand Dissociation Curve Drugs A, B, and C subtitle Drug B Kod 100 Drug A Drug A Kcd Drug B 80 Drug C. Drug C Kod 40 30 10 10 30 50 Ligand concentration (nM)

Explanation / Answer

Answer:

1)

Kd or the steady state dissociation constant of the drug

Kd of the drug refers to the concentration at which fractional occupancy of binding sites by drug molecules is 50%. It is a useful measure to determine the strength of binding or affinity of the ligand for the receptor.

A) What is the Kd for drug A?

B) What is the Kd for drug B?

C) What is the Kd for drug C?

2) Which one would be the best drug to interfere with the process of cell division as triggered by activation of the receptor by the normal ligand?

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