1. True/False: The mechanism by which CTLA-4 inhibits T cell activation is by re

Question

1. True/False: The mechanism by which CTLA-4 inhibits T cell activation is by recruiting inhibitory phosphatases.

2. Genetically inherited immunodeficiency diseases can result from defects in nearly any component of the immune response. The most severe forms of immunodeficiency occur when T cells are absent or non-functional. An individual with normal B cells, but an absence of T cells might have a defect in:
A. RAG-1 or RAG-2 recombinase proteins
B. Terminal deoxynucleotidyl transferase (TdT)
C. Hematopoietic stem cells
D. Bone marrow stromal cells
E. Thymic stromal cells

3. The thymic cortex has a substantial population of macrophages in addition to the developing T cells (i.e., thymocytes). These macrophages are extremely useful in:
A. Eliminating bacterial infections in the thymus
B. Producing cytokines that promote T cell maturation
C. Engulfing apoptotic thymocytes
D. Maintaining the structural integrity of the thymic organ
E. Inducing inflammatory signals to increase blood flow to the thymus

Explanation / Answer

1- True

2- E - This is usually seen in Digeorge syndrome characterised by thymic hypoplasia

3-B,C

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