1. Using the information provided in the table below, calculate the coefficient

Question

1. Using the information provided in the table below, calculate the coefficient of linkage disequilibrium for a single haplotype in the two populations below and indicate if the population is in linkage equilibrium (no bias) or disequilibrium (bias in the association between alleles) for the haplotype by calculating D (you may want to review the slides in the Powerpoint presentation). Show your work. (2 points for this one) Population fA= 0.3 and /B-0.8 hAB = 0.62 Population 2 fA= 0.5 and fB= 0.1 hAB = 0.05 This population is in This population is in 2. This question refers to the total degree of linkage disequilibrium for all haplotypes in a population, not just one as in the question above. In this population the frequency of A is 0.2 and a is 0.8, while the frequency of B is 0.3 and b is 0.7. The haplotype frequencies are: AB = 0.02 Ab=0.23 aB 0.35 ab = 0.40 Calculate the total coefficient of linkage disequilibrium, D, for these haplotypes. (1) Compared to the maximum possible degree of linkage disequilibrium, this suggests a (circle one) low / moderate /high level of linkage disequilibrium. (1) 3. True or False: () Genetic drift can produce linkage disequilibrium. ) Recombination can dissipate linkage disequilibrium. ) Mutations can produce linkage disequilibrium. ) Migration cannot produce linkage disequilibrium. () Natural selection can produce linkage disequilibrium.

Explanation / Answer

3) a True. Genetic drift leads to change in allele frequncies causing variation in the number of alleles in the population.

b) True.

c) True

d) False. Migration increases linkage disequilibrium

e) True

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