2. Using the peak (Action Potential) permeabilities what is the calculated membr

Question

2. Using the peak (Action Potential) permeabilities what is the calculated membrane potential (realizing that the peak permeabilities do not coincide, therefore this is a theoretical number)

HW5 - Read-Only - Compatibility Mode Surbhi Mehta - × File Insert Draw Design Layout References Mailings Review View Help Tell me what you want to do Share- Find - AaBbCcl AaBbC -ab Replace Paste 1 Normal No Spac... Heading abe X2 Select Font Paragraph Editing Problem set 5: Synapses (12 points) Potentially useful information: Nernst Equation (for cations): E(mV) = 61 log(Co/Ci) Goldman Equation: Em V)-6l logNPr(KJ+Pe[Cn The following conditions apply to the next three questions Intracellular mlA) 12 118 10 Ion Extracellular (mlM) 142 4.0 110 Permeability (rest) Permeability (Peak, AP) 25 Na* Kt Ch 0.04 4.0 0.5 0.5 1. What is the resting membrane potential for the conditions given above? Page 1 of 2 237 words 100% 4:48 PM 0 Type here to search "da 2/28/2018

Explanation / Answer

Given:

pK= 1

pNa= 0.04

pCl= 0.5

[K+]in =118

[K+]out=4

[Na+]in=12

[Na+]out=142

[Cl+]in= 10

[Cl+]out= 110

thus,

Vm=E(mV)=61 log [(0.04*142+1*4+0.5*10)/(0.04*12+1*118+0.5*110)]

=61 log [(5.68+4+5)/(0.48+118+55)]

=61 log[14.68/173.48]

=61 log 0.0846

=61* (-1.0726)

=-65.4304

Thus, the resting membrane potential, E= -65.4304mV

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