chig disease (aka ALS, amyotrophic lndion of ror 4 Genetics1212 Gehrig disease (

Question

chig disease (aka ALS, amyotrophic lndion of ror 4 Genetics1212 Gehrig disease (aka ALS, amyotrophic lateral sclerosis) is a condition of Exam 2 S2018 ss and wasting of skeletal muscles due to degeneration of the motor ne es due to degeneration of the motor neurons. It equally affects both men and women. About 10% of ALS cases run in families an d result from expansion in C9orf72 gene. The presence of such repeats in the mRNA of the C9or72 gene lead to production of neurotoxic dipeptide repeats Pro-Arg when the repeats are translated by ribosomes. What type of inheritance is exhibited by this type of familial ALS: A) X-linked recessive B) Autosomal recessive C) Codominance D) X-linked dominant E) Autosomal dominant F) Incomplete dominance she lost her husband Jill's father due to ALS when Jill was a 10 y.o. girl. Jack and Jill have a daughter. What is the probability that the daughter has inherited ALS? Show your work 21.Jack's wife Jill was diagnosed with ALS in her 40s. ills mother is devastated to hear the news;

Explanation / Answer

20. Option E is correct.

ALS shows autosomal dominant inheritance pattern.

The gene responsible for ALS is located on autosomes.

A single copy of the defective allele can cause disease.

21.

A = WT allele

Ad = Dominant disease-causing allele

Jack = AA

Jill = AAd

Jill's father = AAd

Jack X Jill = AA X AAd

Progeny: AA AAd AA AAd

The probability for their progeny to inherit the disease causing allele = 1/2 = 0.5 = 50%

The probability for their progeny to exhibit the disease = 1/2 = 0.5 = 50%

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