Osman, Cell Bio 3201, SPRING 2018 4-26 Sheets can participate in the formation o

Question

Osman, Cell Bio 3201, SPRING 2018 4-26 Sheets can participate in the formation of amyloid fibers, which are insoluble protein aggregates. What drives the formation of amyloid fibers? (a) denaturation of proteins containing sheets (b) extension of sheets into much longer strands (c) formation of biofilms by infectious bacteria (d) -sheet stabilization of abnormally folded proteins 4-27 Protein structures have several different levels of organization. The primary structure of a protein is its amino acid sequence. The secondary and tertiary structures are more complicated. Consider the definitions below and select the one that best fits the term "protein domain. (a) a small cluster of helices and sheets (b) the tertiary structure of a substrate-binding pocket (c) a complex of more than one polypeptide chain (d) a protein segment that folds independently 4-28 The protein structure in Figure Q4-28 contains four helices arranged in a bundle. Label each helix by number (1 to 4) starting from the N-terminus and going to the C-terminus both of which are labeled. List the six possible pairings of these helices, and indicate within each pair whether the helices are parallel or antiparallel. Figure Q4-28 4-29 For each polypeptide sequence listed, choose from the options given below to indicate which secondary structure the sequence is most likely to form upon folding. The nonpolar amino acids are italicized. A. Leu-Gly-Val-Leu-Ser-Leu-Phe-Ser-Gly-Leu-Met-Trp-Phe-Phe-Trp-Ie B· Leu-Leu-Gln-Ser-Ile-Ala-Ser-Val-Leu-GIn-Ser-Leu-Leu-Cys-Ala-Ile C. Thr-Leu-Asn-lle-Ser-Phe-Gln-Met-Glu-Leu-Asp-Val-Ser-Ile-Arg-Trp hydrophilic sheet amphipathic helix Page 7 of 20

Explanation / Answer

4-26= option c is right because Amploids have been linked to the development of various disease ,pathogenic amploids form when protein lose their normal physiological functions and form pathogenic amploids fibre.

4-27=It fold independently because it is conserved part of protein structure so option d is correct.

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