Based on this text, What is the impact of Metagenomics on Gnotobiotic Studies? f

Question

Based on this text, What is the impact of Metagenomics on Gnotobiotic Studies?

file:///D:/Special%20Topics/Week%206/Gordon%20and%20Gut%20Microbio e%20-The%20effect%20of%20Diet%20on%20Human RESEARCH ARTICLE GENETICS AND DIET The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice Peter J. Turnbaugh,' Vanessa K. Ridaura,1 Jeremiah J. Faith,' Federico E. Rey," Rob Knight, Jeffrey I. Gordon (Published 11 November 2009; Volume 1 Issue 6 6ra14) Diet and nutritional status are among the most important modifiable determinants of human health. The nutritional value of food is influenced in part by a person's gut microbial community (microbiota) and its component genes microbiome). Unraveling the interrelations among diet, the structure and operations of the gut microbiota, and nutrient and energy harvest is confounded by variations in human environmental exposures, microbial ecology and genotype. To help overcome these problems, we created a well-defined, representative animal model of the human gut ecosystem by transplanting fresh or frozen adult human fecal microbial communities into germ-free C57BL/6J mice. Culture-independent metagenomic analysis of the temporal, spatial, and intergenerational patterns of bacterial colonization that these humanized mice were stably and heritably colonized and reproduced

Explanation / Answer

The metagenomics in humanized gnotobiotic mice helps us to study the interrelationships between diet, the structure and operations of the gut microbiota, and nutrient and energy harvest is confounded by variations in human environmental exposures, microbial ecology and genotype. In addition, this study also enables us to know about the bacterial pattern of colonization, and the preferable environment of bacterial reproduction.

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