#4: Enzyme Inhibition Study the Figure 4A.1, part a (pg 130 of textbook), which

Question

#4: Enzyme Inhibition

Study the Figure 4A.1, part a (pg 130 of textbook), which presents a multi-enzyme production pathway for the production of lysine, methionine, isoleucine, and threonine.

What type of inhibition is represented by the action of L-lysine produced?

What type of enzyme inhibition process is occurring at enzymes a, b and c, wherein the entire enzyme reaction scheme does not become blocked when L-lysine or L-threonine build up as products?

aspartic - homo- L-threonine semi- L-aspartic acidaspartyl aldehydeserine phosphate L-methionine- L-L-isoleucine L-lysine L-threonine a-ketobutyric acid pyruvic acid -keto, sovaleric acid L-leucine T -L-isoleucine L-valine Figure 4A.1 A simplified diagram of the aspartate pathway in E. coli. Each solid arrow designates a reaction catalyzed by one enzyme. The biosynthetic products of the pathway (in boldface) are all allosteric inhibitors of one or more reactions. Careful study of this di- agram reveals that with a single exception (the inhibition exerted by valine) the inhibition imposed by one amino acid does not cause starvation for a different amino acid. Part (a) shows the regulatory interrelationships of the L-lysine, 1-methionine, and i-isoleucne branches of the pathway. Part (b) shows the regulatory L-isoleucine, L-valine, and I-leucine branches interrelationships of

Explanation / Answer

Answer - End product inhibition

L-lysine blocks the first enzymatic reaction in the chain of reactions for synthesis of L-lysine .

Feedback inhibition process is occuring at enzymes a,b and c.

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